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KMID : 0351219940260040341
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Korean Journal of Infectious Diseases
1994 Volume.26 No. 4 p.341 ~ p.348
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Prevalence of Extended Broad-Spectrum beta-lactamase in Escherichia coli and Klebsiella pneumoniae
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이경원
조성란/이창숙/정윤섭/권오헌
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Abstract
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Background:
@EN Third generation cephalosporins were very active against gram-negative bacilli, however increased resistance to these drugs was noted recently, and this study was to de termine the prevalence of cefotaxime resistance and extended
broad-spectrumβ-lactamase (EBS-Bla) in E. coli and K. pneumoniae.
@ES Methods:
@EN Cefotaxime resistance was analyzed from the data obtained by NCCLS disk diffusion method during 1986 and 1993 at Severance hospital, One hundred eighty-seven strains (79 of E. coli and 108 of K. pneumoniae) isolated in 1994, were examined for
EBS-Bla by double disk synergy test using cefotaxime and amoxicillin/clavulanic acid disks.
@ES Results:
@EN Cefotaxime-resistance rates increased from 1% to 11% in E. coli and from 6% to 30% in K. pneumoniae respectively for the recent 8 years. The isolates from ICU patients showed higher resistance rates than those from general wards or
outpatient.
clinics. Among those which showed intermediate or resistant to cefotaxime, 69% of E. coli and 76% of K. pneumoniae isolates were EBS-Bla producers.
@ES Conclusions:
@EN The cefotaxime-resistant strians of E. coli and K. pneumoniae are increasing in proportion, EBS-Bla-producing strains are common among them, and it is needed to investigate the detailed properties of EBS-Bla to make the guidelines for the
therapeutic regimens and the prevention of transmission of EBS-Bla-producing strains.
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